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Estimating the accuracy of multiple alignments and its use in parameter advising proceedings of the 16th conference on research in computational molecular biology recomb 2012 pp 45 59 kececioglu jd deblasio df accuracy estimation and parameter advising for protein multiple sequence alignment journal of computational biology. This book develops a new approach called parameter advising for finding a parameter setting for a sequence aligner that yields a quality alignment of a given set of input sequences in this framework a parameter advisor is a procedure that automatically chooses a parameter setting for the input and has two main ingredients. Download parameter advising for multiple sequence alignment computational biology or any other file from books category http download also available at fast speeds. While the multiple sequence alignment output by an aligner strongly depends on the parameter values used for the alignment scoring function such as the choice of gap penalties and substitution . Parameter advising for multiple sequence alignment dan deblasio john kececioglu from tenth international society for computational biology iscb student council symposium 2014 boston ma usa 11 july 2014 background while the multiple sequence alignment output by an aligner strongly depends on the parameter values used for its alignment